Melanin is the most important factor to determine skin color. Many research efforts are being undertaken to decompose the already-produced melanin compounds in skin for beauty. This research investigated the effects on reducing melanin color of the three antioxidant enzymes, Glutathione peroxidase (GPX), Thiol peroxidase (TPX), and Catalase, in lysosomal fraction. Melanin solution was treated with the enzymes and hydrogen peroxide, then reacted for 48 h. GPX and TPX decolorized melanin, and between them, GPX was more efficient, but Catalase was not effective. GPX also inhibited the production of melanin in B16F10 melanoma cells. GPX, which is present in almost all microorganisms, plays an important role in the cellular defense mechanism by reactive oxygen species. In addition, it was not cytotoxic, but was significantly effective in decolorizing melanin color. Therefore, in the biological and microbiological field, its possibility of utilization in skin whitening cosmetic is high.

黑色素是决定肤色的最重要因素。正在进行许多研究工作以分解皮肤中已经产生的黑色素化合物以达到美容目的。本研究调查了溶酶体部分中三种抗氧化酶谷胱甘肽过氧化物酶 (GPX)、硫醇过氧化物酶 (TPX) 和过氧化氢酶对减少黑色素颜色的影响。黑色素溶液用酶和过氧化氢处理，然后反应 48 小时。GPX和TPX对黑色素进行脱色，其中GPX更有效，但过氧化氢酶无效。GPX 还抑制 B16F10 黑色素瘤细胞中黑色素的产生。GPX几乎存在于所有微生物中，在活性氧的细胞防御机制中起着重要作用。此外，它没有细胞毒性，但对黑色素颜色的脱色效果显着。因此，在生物和微生物领域，其在美白化妆品中的应用可能性很大。