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Synthesis of Superparamagnetic Zinc Ferrite Encased Fluorapatite Nanoparticles and Its Cytotoxicity Effects on MG-63 Cells
Journal of Cluster Science ( IF 2.7 ) Pub Date : 2021-01-02 , DOI: 10.1007/s10876-020-01946-w
S. Karthi , P. Vivek , D. Karthickraja , G. A. Kumar , C. Dannangoda , K. S. Martirosyan , D. K. Sardar , E. K. Girija

Zinc ferrite (ZnFe2O4) nanoparticles encased fluorapatite (FAP) nanorods was successfully synthesized through hydrothermal method for biomedical applications. TEM image revealed the formation of ZnFe2O4 nanoparticle encased FAP nanorods with average size of about 60 ± 40 nm. Both ZnFe2O4 and ZnFe2O4–FAP samples exhibited superparamagnetic nature at 300 K with saturation magnetization (Ms) of 28.41 and 4.13 emu/g, respectively. Further, the superparamagnetic property of the ZnFe2O4 was investigated using langevin function and average magnetic moment per particle was found to be 606 \({\mu }_{B}\). ZnFe2O4–FAP nanorods exhibited enhanced colloidal stability when compared to ZnFe2O4 nanospheres. The cytotoxicity results confirmed the enhanced cell viability (86%) at 500 µg/mL of ZnFe2O4–FAP nanorods than that of ZnFe2O4 nanospheres (76%). The above results indicate that the ZnFe2O4–FAP nanorods can be considered as a potential candidate for biomedical applications.



中文翻译:

超顺磁性锌铁氧体包裹氟磷灰石纳米粒子的合成及其对MG-63细胞的细胞毒性作用

通过水热法成功地合成了包裹有氟磷灰石(FAP)纳米棒的铁氧体(ZnFe 2 O 4)纳米颗粒,用于生物医学应用。TEM图像揭示了包裹ZnFe 2 O 4纳米颗粒的FAP纳米棒的形成,其平均大小约为60±40 nm。ZnFe 2 O 4和ZnFe 2 O 4 -FAP样品在300 K时均表现出超顺磁性,饱和磁化强度(Ms)分别为28.41和4.13 emu / g。此外,ZnFe 2 O 4的超顺磁性使用兰格文函数进行了研究,发现每个粒子的平均磁矩为606 \({\ mu} _ {B} \)。与ZnFe 2 O 4纳米球相比,ZnFe 2 O 4 –FAP纳米棒表现出增强的胶体稳定性。细胞毒性结果证实,ZnFe 2 O 4 -FAP纳米棒在500 µg / mL时的细胞活力比ZnFe 2 O 4纳米球(76%)增强(86 %)。以上结果表明,ZnFe 2 O 4 -FAP纳米棒可被视为生物医学应用的潜在候选者。

更新日期:2021-01-02
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