In the present work, we propose the synthesis of novel nicotinamide subsituted phthlocyanine photosensitizer (PS) and characterized by FTIR, UV-visible, H-NMR and MALDI Toff spectroscopy. Nicotinamide plays a vital rule in the central nervous system and its potential as a therapeutic for neurodegenerative disease. Nicotinamide substituted PS (3) efficiently produced ROS via type-1 process as measured by DCF assay. We observed that our PS after red light illumination (22 J/cm2) killed gram positive S. aureus upto 3 log reduction. Furher the addition of Potassium Iodide (100 mM) significantly potentiated PS at lower concentrations and enhanced the bacterial killing upto 6 log reduction against the S. aureus. We further found that the synergistic effect of PS and KI also eradicated the gram negative E. coli strain at lower concentraion of PS and found to killed E. coli upto 5 log reduction under the red light illumination at 22 J/cm2 of light dose. The conjugation of such biologically important form of vitamin B3 with PS would be a great addition and could pav the way for the novel photodynamic agent in the treatement of cancer and infectious diseases. A new symmetrical Nicotinamide tetrasubstituted zinc phthalocyanine (3) was synthesized. Upon addition of potassium Iodide with PS, the PS exhibited significant photodynamic activity with 5-6 logs reduction in bacterial load was achieved.

中文翻译：

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新型烟酰胺取代酞菁的合成和碘化钾增强对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌的光动力抗菌化疗评价

在目前的工作中，我们建议合成新型烟酰胺取代的酞菁光敏剂 (PS)，并通过 FTIR、UV-visible、H-NMR 和 MALDI Toff 光谱表征。烟酰胺在中枢神经系统及其作为神经退行性疾病治疗剂的潜力中起着至关重要的作用。烟酰胺取代的 PS (3) 通过 DCF 测定法测量的 1 类过程有效地产生了 ROS。我们观察到红光照射 (22 J/cm2) 后我们的 PS 杀死了革兰氏阳性金黄色葡萄球菌，最多减少 3 个对数。此外，碘化钾 (100 mM) 的添加显着增强了较低浓度的 PS，并增强了对金黄色葡萄球菌的细菌杀灭率，最多可减少 6 log。我们进一步发现 PS 和 KI 的协同作用也根除革兰氏阴性大肠杆菌。PS 浓度较低的大肠杆菌菌株，发现在 22 J/cm2 光剂量的红光照射下杀死大肠杆菌最多 5 log。这种具有生物学意义的维生素 B3 与 PS 的结合将是一个很好的补充，可以为治疗癌症和传染病的新型光动力剂铺平道路。合成了一种新的对称烟酰胺四取代锌酞菁(3)。在加入碘化钾和 PS 后，PS 表现出显着的光动力活性，细菌负荷减少了 5-6 个对数。这种具有生物学意义的维生素 B3 与 PS 的结合将是一个很好的补充，可以为治疗癌症和传染病的新型光动力剂铺平道路。合成了一种新的对称烟酰胺四取代锌酞菁(3)。在加入碘化钾和 PS 后，PS 表现出显着的光动力活性，细菌负荷减少了 5-6 个对数。这种具有生物学意义的维生素 B3 与 PS 的结合将是一个很好的补充，可以为治疗癌症和传染病的新型光动力剂铺平道路。合成了一种新的对称烟酰胺四取代锌酞菁(3)。在加入碘化钾和 PS 后，PS 表现出显着的光动力活性，细菌负荷减少了 5-6 个对数。