A wireless and battery-less trimodal neural interface system-on-chip (SoC), capable of 16-ch neural recording, 8-ch electrical stimulation, and 16-ch optical stimulation, all integrated on a 5 ×  3 mm2 chip fabricated in 0.35-μm standard CMOS process. The trimodal SoC is designed to be inductively powered and communicated. The downlink data telemetry utilizes on–off keying pulse-position modulation (OOK-PPM) of the power carrier to deliver configuration and control commands at 50 kbps. The analog front-end (AFE) provides adjustable mid-band gain of 55–70 dB, low/high cut-off frequencies of 1–100 Hz/10 kHz, and input-referred noise of 3.46 μVrms within 1 Hz-50 kHz band. AFE outputs of every two-channel are digitized by a 50 kS/s 10-bit SAR-ADC, and multiplexed together to form a 6.78 Mbps data stream to be sent out by OOK modulating a 434 MHz RF carrier through a power amplifier (PA) and 6 cm monopole antenna, which form the uplink data telemetry. Optical stimulation has a switched-capacitor based stimulation (SCS) architecture, which can sequentially charge four storage capacitor banks up to 4 V and discharge them in selected μLEDs at instantaneous current levels of up to 24.8 mA on demand. Electrical stimulation is supported by four independently driven stimulating sites at 5-bit controllable current levels in ±(25–775) μA range, while active/passive charge balancing circuits ensure safety. In vivo testing was conducted on four anesthetized rats to verify the functionality of the trimodal SoC.

中文翻译：

---

三模态无线植入神经接口片上系统


无线无电池三模态神经接口片上系统 (SoC)，能够进行 16 通道神经记录、8 通道电刺激和 16 通道光学刺激，全部集成在 5 × 3 mm2 芯片上，该芯片制造于0.35微米标准CMOS工艺。三模 SoC 设计用于感应供电和通信。下行链路数据遥测利用电力载波的开关键控脉冲位置调制 (OOK-PPM) 以 50 kbps 的速度传送配置和控制命令。模拟前端 (AFE) 提供 55–70 dB 的可调节中频增益、1–100 Hz/10 kHz 的低/高截止频率以及 1 Hz-50 kHz 范围内 3.46 μVrms 的输入参考噪声乐队。每两个通道的 AFE 输出均由 50 kS/s 10 位 SAR-ADC 数字化，并复用在一起形成 6.78 Mbps 数据流，由 OOK 通过功率放大器 (PA) 调制 434 MHz 射频载波发送出去。 ）和6厘米单极天线，构成上行数据遥测。光刺激采用基于开关电容器的刺激 (SCS) 架构，可按顺序将四个存储电容器组充电至 4 V，并根据需要在选定的 µLED 中以高达 24.8 mA 的瞬时电流水平对其进行放电。电刺激由四个独立驱动的刺激位点支持，电流水平为 ±(25–775) μA 范围内的 5 位可控，而有源/无源电荷平衡电路可确保安全。对四只麻醉大鼠进行了体内测试，以验证三模 SoC 的功能。