This article presents the design of an unobtrusive and wireless-enabled blood pressure (BP) monitoring system that is suitable for ambulatory use. By adopting low-profile electromechanical actuators and a compact printed circuit board design, this lightweight device can be worn directly on the occlusive cuff, therefore eliminating the need of a long and obtrusive tubing interconnect between the device and the cuff, as seen in traditional ambulatory BP monitors (ABPM). Instead of executing the BP estimation algorithm directly on the device, the proposed design rather sends the raw oscillometric signal through a Bluetooth Low Energy link, thus granting any Bluetooth-enabled device to gather and process the signal using a dedicated application. This in turn allows to assess several BP estimation algorithms found in the literature without being limited by the device resources. Three of them were tested with the designed prototype and validated with a reference equipment on 11 subjects. Overall, two of the algorithms revealed a mean absolute difference with the reference equipment of less than 5 mmHg and almost zero bias along with a standard deviation of less than 6 mmHg. Reproducibility results shown a mean difference between successive measurements of less than 3.1 mmHg and a standard deviation of less than 2.4 mmHg. The assembled prototype dimensions are 63.8 × 134.8 × 24.8 mm and features an autonomy of 63.1 hours. Comparison with commercial ABPM devices shown that the proposed design is 18% to 33% smaller volume-wise, 5% to 27% weight-wise and height is reduced by 17% to 25%.

中文翻译：

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可穿戴无线示波血压计：一种灵活的动态血压估计工具

本文介绍了一种适用于门诊使用的不显眼且支持无线的血压 (BP) 监测系统的设计。通过采用薄型机电致动器和紧凑的印刷电路板设计，这种轻巧的设备可以直接佩戴在闭塞袖带上，因此无需在设备和袖带之间使用长而突兀的管道互连，就像在传统门诊中看到的那样血压监测器 (ABPM)。所提议的设计不是直接在设备上执行 BP 估计算法，而是通过蓝牙低功耗链路发送原始示波信号，从而允许任何支持蓝牙的设备使用专用应用程序收集和处理信号。这反过来又允许评估文献中发现的几种 BP 估计算法，而不受设备资源的限制。其中三个用设计的原型进行了测试，并用参考设备对 11 个对象进行了验证。总体而言，其中两种算法显示与参考设备的平均绝对差异小于 5 mmHg，偏差几乎为零，标准偏差小于 6 mmHg。重现性结果显示连续测量值之间的平均差异小于 3.1 mmHg，标准偏差小于 2.4 mmHg。组装后的原型尺寸为 63.8 × 134.8 × 24.8 毫米，自主性为 63.1 小时。与商用 ABPM 设备的比较表明，所提出的设计体积减小 18% 至 33%，重量减小 5% 至 27%，高度减小 17% 至 25%。