In recent years, electroceuticals have been spotlighted as an emerging treatment for various severe chronic brain diseases, owing to their intrinsic advantage of electrical interaction with the brain, which is the most electrically active organ. However, the majority of research has verified only the short-term efficacy through acute studies in laboratory tests owing to the lack of a reliable miniaturized platform for long-term animal studies. The construction of a sufficient integrated system for such a platform is extremely difficult because it requires multi-disciplinary work using state-of-the-art technologies in a wide range of fields. In this study, we propose a complete system of an implantable platform for long-term preclinical brain studies. Our proposed system, the extra-cranial brain activator (ECBA), consists of a titanium-packaged implantable module and a helmet-type base station that powers the module wirelessly. The ECBA can also be controlled by a remote handheld device. Using the ECBA, we performed a long-term non-anesthetic study with multiple canine subjects, and the resulting PET-CT scans demonstrated remarkable enhancement in brain activity relating to memory and sensory skills. Furthermore, the histological analysis and high-temperature aging test confirmed the reliability of the system for up to 31 months. Hence, the proposed ECBA system is expected to lead a new paradigm of human neuromodulation studies in the near future.

中文翻译：

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可用于未来微创人类神经调节的颅外脑激活器 (ECBA) 系统的长期非麻醉性临床前研究

近年来，由于电药物与大脑电相互作用的内在优势，电药物作为各种严重慢性脑部疾病的新兴疗法备受关注，而大脑是电最活跃的器官。然而，由于缺乏用于长期动物研究的可靠小型化平台，大多数研究仅通过实验室测试中的急性研究来验证短期疗效。为这样一个平台构建一个足够集成的系统是极其困难的，因为它需要使用广泛领域的最先进技术进行多学科工作。在这项研究中，我们为长期临床前脑研究提出了一个完整的可植入平台系统。我们提出的系统，颅外脑激活器（ECBA），由一个钛封装的植入式模块和一个头盔式基站组成，该基站为模块无线供电。ECBA 也可以由远程手持设备控制。使用 ECBA，我们对多个犬科动物进行了长期非麻醉研究，结果 PET-CT 扫描显示与记忆和感官技能相关的大脑活动显着增强。此外，组织学分析和高温老化测试证实了该系统长达 31 个月的可靠性。因此，拟议的 ECBA 系统有望在不久的将来引领人类神经调节研究的新范式。我们对多个犬科动物进行了长期非麻醉研究，结果 PET-CT 扫描显示与记忆和感官技能相关的大脑活动显着增强。此外，组织学分析和高温老化测试证实了该系统长达 31 个月的可靠性。因此，拟议的 ECBA 系统有望在不久的将来引领人类神经调节研究的新范式。我们对多个犬科动物进行了长期非麻醉研究，结果 PET-CT 扫描显示与记忆和感官技能相关的大脑活动显着增强。此外，组织学分析和高温老化测试证实了该系统长达 31 个月的可靠性。因此，拟议的 ECBA 系统有望在不久的将来引领人类神经调节研究的新范式。