The sirtuins family is well known by its unique nicotinamide adenine dinucleotide (NAD⁺)-dependent deacetylase function. The most-investigated member of the family, Sirtuin 1 (SIRT1), accounts for deacetylating a broad range of transcription factors and coregulators, such as p53, the Forkhead box O (FOXO), and so on. It serves as a pivotal regulator in various intracellular biological processes, including energy metabolism, DNA damage response, genome stability maintenance and tumorigenesis. Although the most attention has been focused on its intracellular functions, the regulatory effect on extracellular microenvironment remodeling of SIRT1 has been recognized by researchers recently. SIRT1 can regulate cell secretion process and participate in glucose metabolism, neuroendocrine function, inflammation and tumorigenesis. Here, we review the advances in the understanding of SIRT1 on remodeling the extracellular microenvironment, which may provide new ideas for pathogenesis investigation and guidance for clinical treatment.

中文翻译：

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SIRT1对细胞外微环境重塑的调控作用

Sirtuins 家族以其独特的烟酰胺腺嘌呤二核苷酸 (NAD ⁺) 依赖的脱乙酰酶功能。该家族中研究最多的成员，Sirtuin 1 (SIRT1)，负责使广泛的转录因子和共调节剂脱乙酰化，例如 p53、Forkhead box O (FOXO) 等。它是各种细胞内生物过程的关键调节剂，包括能量代谢、DNA 损伤反应、基因组稳定性维持和肿瘤发生。尽管最受关注的是其细胞内功能，但最近研究人员已经认识到 SIRT1 对细胞外微环境重塑的调节作用。SIRT1可以调节细胞分泌过程，参与糖代谢、神经内分泌功能、炎症和肿瘤发生。在这里，我们回顾了 SIRT1 在重塑细胞外微环境方面的进展，