People with intellectual disability (ID) experience cardiometabolic related morbidity and mortality. However, it has been suggested that this population present and live with underestimated cardiovascular risk factors at a younger age, hence affecting their overall health, quality of life and contributing to early mortality. We assessed autonomic nervous system function in subjects with ID (n=39), aged 18-45 years, through measures of sudomotor function, heart rate and systolic blood pressure variability, and cardiac baroreflex function. Traditional clinical cardiovascular measurements and a biochemical analysis were also undertaken. We found that young adults with ID presented with sudomotor dysfunction, and impaired cardiac baroreflex sensitivity and systolic blood pressure variability, when compared to age-matched control subjects (n=38). Reduced hand and feet electrochemical skin conductance and asymmetry were significantly associated with having a moderate-profound ID. Autonomic dysfunction in those with ID persisted after controlling for age, sex and other metabolic parameters. Subjects in the ID group also showed significantly increased blood pressure, body mass index, waist/hip circumference ratio, and increased plasma haemoglobin A1c and high sensitivity C reactive protein. We conclude that autonomic dysfunction is present in young adults with ID and is more marked in those with more severe disability. These finding have important implications in developing preventative strategies to reduce the risk of cardiovascular disease in people with ID.

中文翻译：

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评估智障青年的自主神经系统功能障碍和心血管疾病风险

智障人士（ID）患有与心脏代谢有关的发病率和死亡率。然而，已经有人提出，该人群在年轻时出现并生活在被低估的心血管危险因素中，因此影响了他们的整体健康，生活质量并导致了早期死亡。我们通过测量运动功能，心率和收缩压变异性以及心脏压力反射功能来评估年龄在18-45岁的ID（n = 39）的受试者的自主神经系统功能。还进行了传统的临床心血管测量和生化分析。我们发现，与年龄相匹配的对照组相比，ID的年轻成年人表现出sudomotor功能障碍，心脏压力反射敏感性和收缩压变异性受损（n = 38）。手脚和脚的电化学皮肤电导率降低和不对称性与具有中等深度的ID显着相关。在控制了年龄，性别和其他代谢参数后，ID患者的自主神经功能障碍仍然存在。ID组的受试者还显示血压，体重指数，腰围/臀围比显着增加，血浆血红蛋白A1c和高敏感性C反应蛋白增加。我们得出的结论是，患有ID的年轻人存在自主神经功能障碍，在残疾程度较严重的成年人中更明显。这些发现对制定预防策略以降低ID人群心血管疾病的风险具有重要意义。在控制了年龄，性别和其他代谢参数后，ID患者的自主神经功能障碍仍然存在。ID组的受试者还显示血压，体重指数，腰围/臀围比显着增加，血浆血红蛋白A1c和高敏感性C反应蛋白增加。我们得出的结论是，患有ID的年轻人存在自主神经功能障碍，在残疾程度较严重的成年人中更明显。这些发现对制定预防策略以降低ID人群心血管疾病的风险具有重要意义。在控制了年龄，性别和其他代谢参数后，ID患者的自主神经功能障碍仍然存在。ID组的受试者还显示血压，体重指数，腰围/臀围比显着增加，血浆血红蛋白A1c和高敏感性C反应蛋白增加。我们得出的结论是，患有ID的年轻人存在自主神经功能障碍，在残疾程度较严重的成年人中更明显。这些发现对制定预防策略以降低ID人群心血管疾病的风险具有重要意义。血浆血红蛋白A1c和高敏感性C反应蛋白增加。我们得出的结论是，患有ID的年轻成年人存在自主神经功能障碍，在残疾较严重的成年人中更明显。这些发现对制定预防策略以降低ID人群心血管疾病的风险具有重要意义。并增加血浆血红蛋白A1c和高敏感性C反应蛋白。我们得出的结论是，患有ID的年轻人存在自主神经功能障碍，在残疾程度较严重的成年人中更明显。这些发现对制定预防策略以降低ID人群心血管疾病的风险具有重要意义。