Chirality is a fundamental property in many biologic systems. Motivated by previous observations of helical aortic blood flow, aortic tissue fibers, and propagation of aortic dissections, we introduce methods to characterize helical morphology of aortic dissections. After validation on computer generated phantoms, the methods were applied to patients with type B dissection. For this cohort, there was a distinct bimodal distribution of helical propagation of the dissection with either achiral or exclusively right-handed chirality, with no intermediate cases or left-handed cases. This clear grouping indicates that dissection propagation favors these two modes, potentially due to the right-handedness of helical aortic blood flow and cell orientation. The characterization of dissection chirality and quantification of helical morphology advances our understanding of dissection pathology and lays a foundation for applications in clinical research and treatment practice. For example, the chirality and magnitude of helical metrics of dissections may indicate risk of dissection progression, help define treatment and surveillance strategies, and enable development of novel devices that account for various helical morphologies.

中文翻译：

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B型主动脉夹层中真实管腔螺旋形态和手性的定量

手性是许多生物系统的基本属性。基于先前对螺旋状主动脉血流，主动脉组织纤维和主动脉夹层的传播的观察，我们引入了表征主动脉夹层螺旋形态的方法。在计算机生成的体模上验证后，该方法适用于B型解剖患者。对于这个队列，解剖学的螺旋传播具有明显的双峰分布，具有非手性或仅右手性手征，没有中间病例或左手病例。这种清晰的分组表明解剖扩散有利于这两种模式，这可能是由于主动脉螺旋状血流的右手性和细胞取向所致。解剖手性的表征和螺旋形态的定量化提高了我们对解剖病理学的理解，并为在临床研究和治疗实践中的应用奠定了基础。例如，解剖的螺旋度量的手性和大小可能指示解剖进展的风险，有助于定义治疗和监测策略，并能够开发出解释各种螺旋形态的新型器械。