Multicomponent and One‐pot Syntheses of Quinoxalines,Advanced Synthesis & Catalysis

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Multicomponent and One‐pot Syntheses of Quinoxalines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-12-31 , DOI: 10.1002/adsc.202001219
Lukas Biesen ₁ , Thomas J. J. Müller ₁

Affiliation

Quinoxalines represent bicyclic nitrogen‐containing heterocycles with a wide array of applications. They exhibit a multitude of biological activities relevant in medicinal chemistry as well as a plethora of luminescence properties. Quinoxaline syntheses exploit the whole raft of multicomponent syntheses from domino to sequential or consecutive reactions, harvesting well‐known synthetic concepts and reactions, such as Ugi‐reactions, but also leading to the development of novel reactions and sequences. Diversity‐oriented synthesis and transition metal catalyzed multicomponent reactions open efficient pathways to quinoxalines and quinoxaline‐containing moieties in a one‐pot fashion. This review outlines the underlying reaction‐based principles of multicomponent syntheses of quinoxalines and summarizes recent developments quinoxaline‐directed MCRs, illustrating their scopes.

中文翻译：

喹喔啉的多组分和一锅合成

喹喔啉代表具有广泛应用的双环含氮杂环。它们表现出与药物化学有关的多种生物活性以及大量的发光特性。喹喔啉合成利用了从多米诺到顺序或连续反应的多组分合成的整个筏，收获了众所周知的合成概念和反应，例如Ugi反应，但也导致了新反应和新序列的发展。面向多样性的合成和过渡金属催化的多组分反应以单罐方式打开了通往喹喔啉和含喹喔啉部分的有效途径。本综述概述了喹喔啉多组分合成的基于反应的基本原理，并概述了喹喔啉指导的MCR的最新发展，

更新日期：2021-02-16

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