The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India,Annals of the New York Academy of Sciences

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The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-12-31 , DOI: 10.1111/nyas.14552
Roshine Mary Koshy ₁ , Shajin Thankaraj ₂ , Vijay Anand Ismavel ₃ , Carolin V Solomi ₄

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In this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at-risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies.

中文翻译：

在印度东北部的二级教会医院重新发现硫胺素缺乏症

在本文中，我们报告了在印度东北部偏远乡村教会医院看到的硫胺素缺乏症的不同表现，包括调查、治疗和康复。详细描述了两个案例研究，一个是患有心脏脚气病的婴儿，另一个是患有周围神经病、心肌病和代谢性酸中毒并对补充硫胺素有反应的非酒精性成人。我们与这些临床实体分享了过去 20 年的经验，包括最近的研究和吸取的教训，并提出了识别印度东北部高危人群的方法，改进早期诊断和治疗，并促进预防性公共卫生战略。

更新日期：2020-12-31

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