当前位置: X-MOL 学术Polym. Bull. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Swelling behaviour, rheological property and drug release profile of the anti-inflammatory drug metamizole sodium from xanthan gum–ZnO nanoparticles
Polymer Bulletin ( IF 3.1 ) Pub Date : 2021-01-01 , DOI: 10.1007/s00289-020-03509-5
Selcan Karakus , Ezgi Tan , Merve Ilgar , Yeşim Müge Sahin , Demet Sezgin Mansuroglu , Deniz Ismik , Razium Ali Somroo , Ayben Kilislioglu

In this study, our aim was to determine the effect of the polymer matrix on the drug delivery system; active-drug-loaded xanthan-gum (XaG)-based ZnO nanoparticles were synthesized under the ultrasonic irritation method. We characterized the structure using UV–Vis, SEM–EDX, FTIR and XRD techniques. The morphology of the nanoparticles has been carried out using SEM, and the results revealed that hexagonal disc structures were prepared with a size below 100 nm. The consideration of theoretical error analysis in estimating kinetic model parameters for simulating the drug release profile was incurred, to find a general model applicable to multimechanistic release. Five error analysis methods for identifying the kinetic model parameters have been calculated and their comparison based on goodness of fit. Results showed that drug-loaded XaG/ZnO nanoparticles released the drug with the Higuchi model ( R 2 = 0.97–0.99). We compared the viscosities of nanostructures obtained by using different synthesis methods such as magnetic stirring and ultrasonic irradiation at different times (10–20 min) to illuminate the rheological structure. Comparing Krigbaum and Wall parameters (Δ b ) for all samples, XaG/ZnO nanoparticles synthesized by ultrasonic irritation method proved to be an optimal miscible formulation. From the results, XaG/ZnO nanoparticles can potentially be recommended as a reliable nanocarrier with the release of metamizole sodium (MS) drug.

中文翻译:

黄原胶-氧化锌纳米颗粒中抗炎药安乃近钠的溶胀行为、流变特性和药物释放曲线

在这项研究中,我们的目的是确定聚合物基质对药物递送系统的影响;在超声刺激法下合成了负载活性药物的黄原胶 (XaG) 基 ZnO 纳米颗粒。我们使用 UV-Vis、SEM-EDX、FTIR 和 XRD 技术对结构进行了表征。已使用 SEM 对纳米粒子的形态进行了研究,结果表明制备了尺寸低于 100 nm 的六边形圆盘结构。在估计用于模拟药物释放曲线的动力学模型参数时考虑理论误差分析,以找到适用于多机制释放的通用模型。计算了五种用于确定动力学模型参数的误差分析方法,并根据拟合优度进行比较。结果表明,载药 XaG/ZnO 纳米颗粒以 Higuchi 模型释放药物 (R 2 = 0.97–0.99)。我们比较了通过使用不同的合成方法(如磁力搅拌和超声波照射)在不同时间(10-20 分钟)照亮流变结构而获得的纳米结构的粘度。比较所有样品的 Krigbaum 和 Wall 参数 (Δ b ),通过超声刺激法合成的 XaG/ZnO 纳米颗粒被证明是最佳的混溶配方。从结果来看,XaG/ZnO 纳米颗粒有可能被推荐为一种可靠的纳米载体,可释放安乃近钠 (MS) 药物。我们比较了通过使用不同的合成方法(如磁力搅拌和超声波照射)在不同时间(10-20 分钟)照亮流变结构而获得的纳米结构的粘度。比较所有样品的 Krigbaum 和 Wall 参数 (Δ b ),通过超声刺激法合成的 XaG/ZnO 纳米颗粒被证明是最佳的混溶配方。从结果来看,XaG/ZnO 纳米颗粒有可能被推荐为一种可靠的纳米载体,可释放安乃近钠 (MS) 药物。我们比较了通过使用不同的合成方法(如磁力搅拌和超声波照射)在不同时间(10-20 分钟)照亮流变结构而获得的纳米结构的粘度。比较所有样品的 Krigbaum 和 Wall 参数 (Δ b ),通过超声刺激法合成的 XaG/ZnO 纳米颗粒被证明是最佳的混溶配方。从结果来看,XaG/ZnO 纳米颗粒有可能被推荐为一种可靠的纳米载体,可释放安乃近钠 (MS) 药物。
更新日期:2021-01-01
down
wechat
bug