As global population escalates; the need for better healthcare shall inevitably intensify. Current scenario, thus, calls for a versatile technology for the construction for smart biomaterials to cater to the needs. In this context; hydrogels comprising carboxymethyl chitosan and polyvinyl alcohol (CMCS/ PVA) were fabricated using a green crosslinker, tetraethyl orthosilicate. To enhance their bio-efficacy; cold plasma assisted surface tailoring of the aforesaid hydrogels was performed as a function of four different gases viz Air, Ar, He and N₂. Apart from improving the surface wettability; plasma treatment endowed the hydrogels with an improved tensile strength. 5-Fluorouracil (5FU) release studies from the hydrogels validated their potential as oral colon-targeted delivery systems. Hemolytic experiments revealed no adverse effect on RBCs post-plasma treatment. Pristine hydrogels exhibited good cytocompatibility with MCF-7 cells. A strong cell growth inhibition was observed from 5FU-loaded hydrogels as validated by caspase-3 assay. Further assessment by the soil burial test revealed the hydrogels were biodegradable. Among all, the Ar-plasma treated hydrogel demonstrated superior hemocompatibility, chemosensitivity and biodegradability. Thus, cold plasma technology has invariably paved the path as an eco-friendly, economical and effectual strategy for development of novel CMCS/ PVA hydrogels in anticancer therapy.

随着全球人口的增长；对更好的医疗保健的需求将不可避免地加剧。因此，当前方案要求用于智能生物材料构造的多功能技术来满足需求。在这种情况下；使用绿色交联剂原硅酸四乙酯制造了包含羧甲基壳聚糖和聚乙烯醇（CMCS / PVA）的水凝胶。增强其生物功效；上述水凝胶的冷等离子体辅助表面修整是根据四种不同气体（即空气，氩气，氦气和氮气_2）的函数进行的。除了改善表面润湿性外；等离子体处理使水凝胶具有改善的拉伸强度。从水凝胶中释放5-氟尿嘧啶（5FU）的研究证实了它们作为口服结肠靶向递送系统的潜力。溶血实验显示对血浆处理后的红细胞无不良影响。原始的水凝胶与MCF-7细胞表现出良好的细胞相容性。如caspase-3分析所证实，从5FU负载的水凝胶中观察到了强烈的细胞生长抑制作用。通过土壤掩埋测试的进一步评估表明水凝胶是可生物降解的。其中，经Ar等离子处理的水凝胶具有优异的血液相容性，化学敏感性和生物降解性。因此，冷等离子体技术始终为生态友好型铺平了道路，