It has come to our notice that there was an inadvertent misupload of Fig. 2 (c, d) in the loading control (GAPDH) for ASIC1a and NLRP1 blots. We would like to replace the same with the correct image. This change anyhow does not affect the conclusion of the study. However, the use of GAPDH as a loading control for stroke studies sometimes is debatable (Zhai et al. 2014; Kang et al. 2018). Hence, we repeated our experiments to check the expression of ASIC1a and NLRP1 at different time points following stroke, using beta actin as a loading control. We found that at 24 h post stroke, maximal and significant expression of both ASIC1a and NLRP1 was observed (Fig. 2 e, f). The expression at 48 and 72 h post stroke were not significantly different as compared to that of sham. The expression results obtained using beta actin as a loading control were concurrent with the previous results published with GAPDH as a loading control.

我们注意到，在ASIC1a和NLRP1印迹的上样对照（GAPDH）中，图2（c，d）出现了误上载。我们希望将其替换为正确的图像。无论如何，这种变化不会影响研究的结论。然而，使用GAPDH作为中风研究的负荷对照有时是有争议的（Zhai等人2014; Kang等人2018）。因此，我们重复实验以中风后不同时间点使用β-肌动蛋白作为上样对照检查ASIC1a和NLRP1的表达。我们发现在中风后24小时，观察到了ASIC1a和NLRP1的最大且显着表达（图2 e，f）。中风后48和72 h的表达与假手术相比无显着差异。