Recent studies have shown that natural antioxidant compounds have positive effects on the nervous system. Lycopene, the red pigment in tomatoes, is one of the potent natural antioxidants, and is used as supplementation because of its well-known health benefits. However, its effect on epileptic seizures and underlying mechanisms are still unclear. In this study, it was aimed to investigate the effect of lycopene on pentylenetetrazole-induced epileptic seizures in rats and to elucidate the nitric oxide pathway in this effect. In this study, thirty male Wistar albino rats were used. Animals were divided into five groups (n = 6 for each group) as control, saline (1 mL/kg/day serum physiologic), positive control (2 mg/kg/day diazepam), and lycopene (5 and 10 mg/kg/day) for ten days. Pentylenetetrazole (45 mg/kg) was given to induce a seizure in the tenth day except for the control. Passive avoidance test was carried out to evaluate memory function. Inducible nitric oxide synthase (iNOS), neuronal nitric oxide synthase (nNOS), and nitric oxide (NO) levels were measured in the cortex and hippocampal brain regions using the ELISA kits. Lycopene supplementation prolonged epileptic seizure onset times and reduced seizure stages. Besides, lycopene supplementation improved memory impairment after seizures. Moreover, lycopene significantly reduced the level of iNOS, nNOS, and NO in the brain. Lycopene supplementation significantly alleviated seizures and memory impairment. Its anticonvulsive effect could be associated with the nitric oxide pathway. Lycopene supplementation could be useful as a supportive therapeutic agent in epileptic patients.

最近的研究表明，天然抗氧化剂对神经系统有积极作用。番茄红素番茄红素是有效的天然抗氧化剂之一，由于其众所周知的健康益处而被用作补充剂。但是，其对癫痫发作的作用及其潜在机制尚不清楚。在这项研究中，旨在研究番茄红素对戊戊四唑诱发的大鼠癫痫发作的作用，并阐明这种作用中的一氧化氮途径。在这项研究中，使用了三十只雄性Wistar白化病大鼠。动物分为五组（n 每组= 6）作为对照，生理盐水（1 mL / kg /天，地西epa），阳性对照（2 mg / kg /天，地西epa）和番茄红素（5和10 mg / kg /天）进行10天。除对照组外，在第10天给予戊四唑（45mg / kg）诱发癫痫发作。进行被动回避测试以评估记忆功能。使用ELISA试剂盒测量了皮质和海马脑区的诱导型一氧化氮合酶（iNOS），神经元一氧化氮合酶（nNOS）和一氧化氮（NO）的水平。番茄红素的补充可延长癫痫发作的时间并缩短癫痫发作阶段。此外，番茄红素的补充改善了癫痫发作后的记忆障碍。此外，番茄红素显着降低了大脑中iNOS，nNOS和NO的水平。补充番茄红素可显着缓解癫痫发作和记忆力减退。其抗惊厥作用可能与一氧化氮途径有关。番茄红素补充剂可用作癫痫患者的支持治疗剂。