We conducted a pilot randomized controlled trial of a social network-based intervention to promote PrEP adherence among transgender women (TW) in Lima, Peru. We enrolled 89 TW from six social networks and cluster-randomized them 1:1 to standard of care (n = 44) or the TransPrEP intervention (n = 45). Core workshops discussed strategies to support PrEP adherence and defined group adherence objectives. Maintenance workshops discussed participants’ experiences taking PrEP and collective adherence goals. At 3-month follow-up, we evaluated 40 participants and obtained 29 hair samples for tenofovir level measurements. Though no significant differences were observed, 36.4% (4/11) of participants of TransPrEP participants and 10.0% (1/10) of control participants had tenofovir levels > 0.023 ng/mg, consistent with ≥ 4 doses per week. 81.8% (9/11) of intervention and 40.0% (4/10) of control participants had any detectable tenofovir in their hair. Pilot assessment of our network-based intervention suggested a trend towards improved PrEP adherence, measured objectively, for TW in Peru.

我们对基于社交网络的干预措施进行了一项随机对照试验，以促进秘鲁利马跨性别女性 (TW) 的 PrEP 依从性。我们从 6 个社交网络招募了 89 名 TW，并以 1:1 的比例将他们随机分组至标准护理 (n = 44) 或 TransPrEP 干预 (n = 45)。核心研讨会讨论了支持 PrEP 依从性的策略并确定了团体依从性目标。维护研讨会讨论了参与者采取 PrEP 的经验和集体遵守目标。在 3 个月的随访中，我们评估了 40 名参与者，并获取了 29 份头发样本来测量替诺福韦水平。尽管没有观察到显着差异，但 TransPrEP 参与者中 36.4% (4/11) 和对照参与者中 10.0% (1/10) 的替诺福韦水平 > 0.023 ng/mg，与每周 ≥ 4 剂剂量一致。81.8% (9/11) 的干预参与者和 40.0% (4/10) 的对照参与者的头发中检测到替诺福韦。对我们基于网络的干预措施的试点评估表明，客观衡量，秘鲁 TW 的 PrEP 依从性有改善的趋势。