Rejuvenated ageing mesenchymal stem cells by stepwise preconditioning ameliorates surgery-induced osteoarthritis in rabbits.,Bone & Joint Research

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Rejuvenated ageing mesenchymal stem cells by stepwise preconditioning ameliorates surgery-induced osteoarthritis in rabbits.
Bone & Joint Research ( IF 4.7 ) Pub Date : 2021-1-1 , DOI: 10.1302/2046-3758.101.bjr-2020-0249.r1
Zhixian Zong ₁ , Xiaoting Zhang _{2,

3} , Zhengmeng Yang _{2,

3} , Weihao Yuan ₄ , Jianping Huang ₅ , Weiping Lin _{2,

3} , Ting Chen ₁ , Jiahao Yu ₁ , Jiming Chen ₁ , Liao Cui ₆ , Gang Li _{2,

3} , Bo Wei ₁ , Sien Lin _{1,

6,

7}

Affiliation

Ageing-related incompetence becomes a major hurdle for the clinical translation of adult stem cells in the treatment of osteoarthritis (OA). This study aims to investigate the effect of stepwise preconditioning on cellular behaviours in human mesenchymal stem cells (hMSCs) from ageing patients, and to verify their therapeutic effect in an OA animal model.

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