Background. RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biological functions of RNA helicase DHX37 in cancers. Objective. We aim to identify the prognostic value of DHX37 associated with tumor microenvironments in cancers. Methods. DHX37 expression was examined via the Oncomine database and Tumor Immune Estimation Resource (TIMER). We explored the prognostic role of DHX37 in cancers across various databases. Coexpression genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and fundamental regulators were performed via LinkedOmics. Confirming the prognostic value of DHX37 in liver hepatocellular carcinoma (LIHC) and lung adenocarcinoma (LUAD), we explored the role of DHX37 in infiltrated lymphocytes in cancers using the Gene Expression Profiling Interactive Analysis (GEPIA) and TIMER databases. Results. Through GO and KEGG analyses, expression of DHX37 was also correlated with complex function-specific networks involving the ribosome and RNA metabolic signaling pathways. In LIHC and LUAD, DHX37 expression showed significant positive correlations with markers of T_regs, myeloid-derived suppressor cells (MDSCs), and T cell exhaustion, contributing to immune tolerance. Conclusion. These results indicate that DHX37 can serve as a prognostic biomarker in LIHC and LUAD while having an important role in immune tolerance by activating the function of T_regs, MDSC, and T cell exhaustion.

中文翻译：

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DHX37通过免疫浸润影响肝细胞癌和肺腺癌的预后

背景。RNA解旋酶在RNA代谢的基本上所有方面都具有各种基本功能，不仅解开RNA，而且干扰RNA与蛋白质的相互作用。最近，RNA解旋酶被认为是癌症的潜在靶标。到目前为止，还没有关于 RNA 解旋酶 DHX37 在癌症中的生物学功能的详细研究。客观。我们旨在确定 DHX37 与癌症中的肿瘤微环境相关的预后价值。方法. 通过 Oncomine 数据库和肿瘤免疫估计资源 (TIMER) 检查 DHX37 表达。我们在各种数据库中探索了 DHX37 在癌症中的预后作用。共表达基因、基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 以及基本调节器通过 LinkedOmics 进行。确认 DHX37 在肝细胞癌 (LIHC) 和肺腺癌 (LUAD) 中的预后价值，我们使用基因表达谱交互分析 (GEPIA) 和 TIMER 数据库探讨了 DHX37 在癌症浸润淋巴细胞中的作用。结果. 通过 GO 和 KEGG 分析，DHX37 的表达也与涉及核糖体和 RNA 代谢信号通路的复杂功能特异性网络相关。在 LIHC 和 LUAD 中，DHX37 表达与 T _regs标志物、髓源性抑制细胞 (MDSC) 和 T 细胞耗竭呈显着正相关，有助于免疫耐受。结论。这些结果表明，DHX37 可作为 LIHC 和 LUAD 的预后生物标志物，同时通过激活 T _regs、MDSC 和 T 细胞耗竭的功能在免疫耐受中发挥重要作用。