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Fluorinated Pyrazoles: From Synthesis to Applications
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-12-31 , DOI: 10.1021/acs.chemrev.0c01015 Pavel K Mykhailiuk 1, 2
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-12-31 , DOI: 10.1021/acs.chemrev.0c01015 Pavel K Mykhailiuk 1, 2
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Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially. Moreover, more than 50% of all contributions on the topic have been published in the last 5 years. In this review, analysis of novel synthetic approaches to fluorinated pyrazoles that appeared in recent years is performed. A particular emphasis is devoted to a detailed consideration of reaction mechanisms. In addition, the reasons that have led to the ever-increasing popularity of fluorinated pyrazoles in various areas of science are discussed. At the end of the review, several potentially interesting but yet mostly unknown classes of fluorinated pyrazoles are outlined.
中文翻译：
氟化吡唑：从合成到应用
氟化吡唑在药物化学、药物发现、农业化学、配位化学和有机金属化学中发挥着重要作用。自 1990 年代初以来，它们的受欢迎程度呈指数级增长。此外，关于该主题的所有贡献的 50% 以上已在过去 5 年内发表。在这篇综述中，对近年来出现的氟化吡唑的新型合成方法进行了分析。特别强调对反应机制的详细考虑。此外，还讨论了导致氟化吡唑在各个科学领域越来越受欢迎的原因。在审查结束时，概述了几种可能有趣但大多数未知的氟化吡唑类。
更新日期：2021-02-10
中文翻译：
氟化吡唑：从合成到应用
氟化吡唑在药物化学、药物发现、农业化学、配位化学和有机金属化学中发挥着重要作用。自 1990 年代初以来，它们的受欢迎程度呈指数级增长。此外，关于该主题的所有贡献的 50% 以上已在过去 5 年内发表。在这篇综述中，对近年来出现的氟化吡唑的新型合成方法进行了分析。特别强调对反应机制的详细考虑。此外，还讨论了导致氟化吡唑在各个科学领域越来越受欢迎的原因。在审查结束时，概述了几种可能有趣但大多数未知的氟化吡唑类。
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