The novel coronavirus (SARS-CoV-2) currently spreads worldwide, causing the disease COVID-19. The number of infections increases daily, without any approved antiviral therapy. The recently released viral nucleotide sequence enables the identification of therapeutic targets, e.g. by analyzing integrated human-virus metabolic models. Investigations of changed metabolic processes after virus infections and the effect of knock-outs on the host and the virus can reveal new potential targets.

中文翻译：

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FBA 揭示鸟苷酸激酶是 SARS-CoV-2 抗病毒治疗的潜在靶点

新型冠状病毒（SARS-CoV-2）目前在全球范围内传播，导致疾病 COVID-19。在没有任何批准的抗病毒治疗的情况下，感染人数每天都在增加。最近发布的病毒核苷酸序列能够识别治疗靶标，例如通过分析整合的人类病毒代谢模型。研究病毒感染后代谢过程的变化以及敲除对宿主和病毒的影响可以揭示新的潜在靶点。