microRNAs (miRNAs) are essential components of gene expression regulation at the post-transcriptional level. miRNAs have a well-defined molecular structure and this has facilitated the development of computational and high-throughput approaches to predict miRNAs genes. However, due to their short size, miRNAs have often been incorrectly annotated in both plants and animals. Consequently, published miRNA annotations and miRNA databases are enriched for false miRNAs, jeopardizing their utility as molecular information resources. To address this problem, we developed MirCure, a new software for quality control, filtering and curation of miRNA candidates. MirCure is an easy-to-use tool with a graphical interface that allows both scoring of miRNA reliability and browsing of supporting evidence by manual curators.

中文翻译：

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MirCure：一种用于动物和植物微RNA质量控制，过滤和处理的工具

microRNA（miRNA）是转录后水平基因表达调控的重要组成部分。miRNA具有明确的分子结构，这促进了预测miRNA基因的计算和高通量方法的发展。但是，由于其小巧的尺寸，miRNA在植物和动物中经常被错误地注释。因此，已发布的miRNA注释和miRNA数据库丰富了错误的miRNA，从而损害了它们作为分子信息资源的实用性。为了解决这个问题，我们开发了MirCure，这是一种用于miRNA候选物质量控制，过滤和管理的新软件。MirCure是一个易于使用的工具，具有图形界面，可以对miRNA可靠性进行评分，也可以通过手动策展人浏览支持证据。