The relationship between gene co-expression and chromatin conformation is of great biological interest. Thanks to high-throughput chromosome conformation capture technologies (Hi-C), researchers are gaining insights on the tri-dimensional organization of the genome. Given the high complexity of Hi-C data and the difficult definition of gene co-expression networks, the development of proper computational tools to investigate such relationship is rapidly gaining the interest of researchers. One of the most fascinating questions in this context is how chromatin topology correlates with gene co-expression and which physical interaction patterns are most predictive of co-expression relationships.

中文翻译：

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通过图嵌入探索染色质构象和基因共表达

基因共表达与染色质构象之间的关系具有重要的生物学意义。多亏了高通量染色体构象捕获技术（Hi-C），研究人员才对基因组的三维组织有了深入的了解。鉴于Hi-C数据的高度复杂性和基因共表达网络的定义困难，研究这种关系的合适计算工具的开发正在迅速引起研究人员的兴趣。在这种情况下，最有趣的问题之一是染色质拓扑如何与基因共表达相关，以及哪些物理相互作用模式最能预测共表达关系。