Metastases cause a vast majority of cancer morbidity and mortality. Metastatic clones are formed by dispersal of cancer cells to secondary tissues, and are not medically detected or visible until later stages of cancer development. Clone phylogenies within patients provide a means of tracing the otherwise inaccessible dynamic history of migrations of cancer cells.

中文翻译：

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PathFinder：癌症克隆迁移历史的贝叶斯推断

转移导致绝大多数癌症发病率和死亡率。转移性克隆是通过癌细胞扩散到次生组织而形成的，直到癌症发展的后期阶段才在医学上检测到或可见。患者体内的克隆系统发育提供了一种追踪癌细胞迁移动态历史的方法，否则这种动态历史是无法获得的。