Micro-RNAs (miRNAs) are known as the important components of RNA silencing and post-transcriptional gene regulation, and they interact with messenger RNAs (mRNAs) either by degradation or by translational repression. miRNA alterations have a significant impact on the formation and progression of human cancers. Accordingly, it is important to establish computational methods with high predictive performance to identify cancer-specific miRNA–mRNA regulatory modules.

中文翻译：

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一个有效的框架来识别癌症中的关键miRNA–mRNA调控模块

微小RNA（miRNA）是RNA沉默和转录后基因调控的重要组成部分，它们通过降解或翻译抑制与信使RNA（mRNA）相互作用。miRNA的改变对人类癌症的形成和发展具有重大影响。因此，建立具有高预测性能的计算方法以识别癌症特异性miRNA–mRNA调控模块非常重要。