Alcohol abuse induces multiple neuropathology and causes global burden to human health. Prefrontal cortex (PFC) is one of the most susceptible regions to alcohol-induced neuropathology. However, precise mechanisms underlying these effects on PFC remain to be elucidated. Herein, we investigated whether RIP1/RIP3/MLKL-mediated necroptosis was involved in the alcohol-induced PFC injury, and explored the effect that cannabinoid receptors (CBRs) exerted on the neurotoxicity of alcohol.

中文翻译：

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CB1R 促进小鼠前额叶皮层慢性酒精诱导的神经元坏死

酒精滥用会诱发多种神经病理学，并对人类健康造成全球负担。前额叶皮层 (PFC) 是对酒精引起的神经病理学最敏感的区域之一。然而，这些对 PFC 影响的确切机制仍有待阐明。在此，我们研究了 RIP1/RIP3/MLKL 介导的坏死性凋亡是否参与了酒精诱导的 PFC 损伤，并探讨了大麻素受体 (CBR) 对酒精神经毒性的影响。