Drug-induced acute liver injury (DIALI) is increasingly recognized as a significant cause of acute liver injury (ALI), which is characterized by a rapid loss of hepatocyte function in patients without pre-existing liver diseases. Evaluation of corresponding biomarkers, including alanine transaminase and aspartate amino transferase, is available as a diagnostic tool for hepatotoxicity. However, these blood tests have certain limitations: (1) they are generally not available for early estimation; (2) it is difficult to visualize and identify hepatotoxicity unambiguously in real-time; and (3) the biomarkers are not unique and are usually influenced by a variety of diseases, leading to potential false results. It is of grave importance and burgeoning demand to develop an early diagnostic approach for such diseases, but the ideal toolkit remains an unresolved challenge.

中文翻译：

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用于药物引起的急性肝损伤成像的荧光探针设计策略

药物诱发的急性肝损伤（DIALI）越来越被认为是急性肝损伤（ALI）的重要原因，其特征是在没有肝病的患者中肝细胞功能迅速丧失。评估相应的生物标志物，包括丙氨酸转氨酶和天冬氨酸转氨酶，可作为肝毒性的诊断工具。但是，这些血液检查有一定的局限性：（1）通常无法进行早期评估；（2）难以实时清晰地观察和识别肝毒性；（3）生物标志物不是唯一的，通常会受到多种疾病的影响，从而导致潜在的错误结果。开发针对此类疾病的早期诊断方法非常重要且需求不断增长，