Abstract

Peptic ulcer is a common disorder of the gastrointestinal system affecting people of all ages worldwide. Ethanol is one of the most common causative agents for peptic ulcer. The aim of this study was to evaluate the protective effect of two newly synthesized indole imines (389 and 393) against ethanol-induced gastric ulcer in rats. Animals were orally administered different treatments: group I–II (vehicle & ulcer controls, respectively); 0.5% aqueous CMC solution, group III (standard control; omeprazole; 20 mg/kg bw); groups IV–VI, test compound 389 (20, 40 and 60 mg/kg bw) and groups VII–IX, test compound 393 (20, 40 and 60 mg/kg bw). Various parameters including pH, gastric contents, ulcer index and percentage protection were determined and histopathological study of gastric mucosa was performed to evaluate the protective effect of the test compounds. Oral administration of the test compounds, i.e. 389 and 393 (20, 40 and 60 mg/kg bw), significantly (p < 0.05) reduced the ulcer index in a dose-dependant manner as compared to the ethanol-induced ulcer control group. The gastroprotective potential of the studied test compounds was supported by the histological examination of the gastric mucosa showing a decreased inflammatory response with less oedema and leucocyte infiltration. The study concluded that the synthesized test compounds possess antiulcerogenic potential possibly due to their anti-inflammatory effects.

摘要

消化性溃疡是胃肠系统的常见疾病，影响全世界所有年龄段的人。乙醇是消化性溃疡最常见的病原体之一。这项研究的目的是评估两种新合成的吲哚亚胺（389和393）对大鼠乙醇诱导的胃溃疡的保护作用。给动物口服不同的治疗方法：I–II组（分别为车辆和溃疡对照组）；0.5％CMC水溶液，III组（标准对照；奥美拉唑； 20 mg / kg体重）；第IV–VI组，测试化合物389（20、40和60 mg / kg bw）和第VII–IX组，测试化合物393（20、40和60 mg / kg bw）。各种参数，包括pH值，胃内容物，确定溃疡指数和保护百分比，并进行胃粘膜的病理组织学研究以评价测试化合物的保护作用。口服试验化合物，即389和393（20、40和60 mg / kg bw），显着（ 与乙醇诱导的溃疡对照组相比，p <0.05）以剂量依赖的方式降低了溃疡指数。胃粘膜的组织学检查显示出炎症反应减少，水肿和白细胞浸润减少，从而支持了所研究测试化合物的胃保护潜力。研究得出结论，合成的受试化合物可能具有抗溃疡作用，这可能是由于其具有抗炎作用。