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New Convenient Routes of Hydrazonoyl Halides for the Synthesis of Novel Thiazoles and Polythiazoles
Polycyclic Aromatic Compounds ( IF 2.4 ) Pub Date : 2020-12-31 , DOI: 10.1080/10406638.2020.1866032
Abdelwahed R. Sayed 1, 2 , Sobhi M. Gomha 3, 4 , Yasair S. Al-Faiyz 1 , Yasser H. Zaki 2
Affiliation  

Abstract

The present effort is to use good organized method for the synthesis of novel thiazoles from the reaction of different α-haloketohydrazonoyl halides with thiosemicarbazones in the basic medium at refux. In addition, new polthiazole was prepared from the reaction of 1,4-phenylene-bis(2-oxopropanehydrazonoyl chloride) with 2,2′-(1,4-phenylenebis(methanyl-ylidene))bis(hydrazine-1-carbothioamide) in the presence of basic medium. The formation of the final thiazoles or polythiazole can be explained through nucleophile substitution of the halogen atom form hydrazonoyl halides, followed by removal of water to give the final products as represented in Schemes. The inexpensive, good yielding, simple reaction conditions, and commercial availability of the chemicals make these methods valuable. The description structures for the final compounds are discussed and suggested. New organic substances were elucidated via FTIR, MS, NMR, and elemental analyses.



中文翻译:

用于合成新型噻唑和聚噻唑的肼酰卤的新便捷途径

摘要

目前的努力是使用良好的组织方法,在回流时在碱性介质中通过不同的 α-卤代酮腙酰卤与氨基硫脲反应合成新型噻唑。此外,由1,4-亚苯基-双(2-氧代丙烷腙酰氯)与2,2'-(1,4-亚苯基双(甲亚基))双(肼-1-硫代甲硫酰胺)反应制备了新型聚噻唑。在碱性介质存在的情况下。最终噻唑或聚噻唑的形成可以通过卤素原子形式的肼酰卤的亲核取代,然后除去水得到最终产物来解释,如方案中所示。廉价、高产率、简单的反应条件和化学物质的商业可得性使这些方法很有价值。讨论并建议了最终化合物的描述结构。通过 FTIR、MS、NMR 和元素分析阐明了新的有机物质。

更新日期:2020-12-31
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