A direct strategy toward the synthesis of functionalized abietane-type diterpenes and related polycyclic molecules was developed through an Au-catalyzed 1,3-acyloxy migration/cyclization/electrophilic aromatic substitution cascade. Unlike the known polyene-type cyclization strategies for the construction of abietane-type diterpene skeletons, propargylic ester groups were used for the cyclization process, which can readily lead to the key skeleton with C2 and C3 functionalization. As a demonstration of the potential application of this tandem reaction, a collective total synthesis of (±)-2-ketoferruginol, (±)-fleuryinol B, (±)-salviol, (±)-2β-acetoxyferruginol, and (±)-2β-acetoxysugiyl methyl ether was achieved. Among these molecules, (±)-fleuryinol B and (±)-2β-acetoxyferruginol were synthesized for the first time.

通过Au催化的1，3-酰氧基迁移/环化/亲电子芳族取代级联反应，开发了一种直接合成官能化枞烷型二萜和相关多环分子的策略。不同于已知的多烯型环戊二烯骨架结构的环化策略，炔丙基酯基团用于环化过程，可以容易地导致关键骨架具有C2和C3官能化。为了证明该串联反应的潜在用途，共合成了（±）-2-酮基铁血红素醇，（±）-荧光白血球醇B，（±）-唾液醇，（±）-2β-乙酰氧基铁血红素醇和（±）获得了-2β-乙酰氧基苏糖基甲基醚。在这些分子中，首次合成了（±）-荧光白蛋白B和（±）-2β-乙酰氧基铁蛋白醇。