Neurons populating the rectal extrinsic nerves in humans express neuronal and Schwann cell markers,Neurogastroenterology & Motility

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Neurons populating the rectal extrinsic nerves in humans express neuronal and Schwann cell markers
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-12-31 , DOI: 10.1111/nmo.14074
Crystal Woods ₁ , Raj P Kapur ₂ , Andrea Bischoff ₃ , Mark Lovell ₄ , Michael Arnold ₄ , Alberto Peña ₃ , Amanda Flockton ₁ , Keith A Sharkey ₅ , Jaime Belkind-Gerson _{1,

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Affiliation

In mice, Schwann cell (SC) progenitors give rise to autonomic ganglion cells and migrate into the gut to become enteric neurons. It is unknown whether SC progenitors have a similar fate in humans. In search of evidence for human SC-derived neurogenesis in the gastrointestinal (GI) tract, we studied the rectums from cadaveric controls and children with anorectal malformations (ARM).

中文翻译：

人类直肠外在神经中的神经元表达神经元和雪旺氏细胞标志物

在小鼠中，雪旺氏细胞 (SC) 祖细胞产生自主神经节细胞并迁移到肠道成为肠神经元。尚不清楚 SC 祖细胞在人类中是否有类似的命运。为了寻找胃肠道 (GI) 中人类 SC 衍生神经发生的证据，我们研究了来自尸体对照和患有肛门直肠畸形 (ARM) 的儿童的直肠。

更新日期：2020-12-31

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