Background

Cryptococcosis is a severe universally distributed mycosis which mainly affects immunocompromised hosts. This mycosis is caused by yeasts of two species complex of the genus Cryptococcus: Cryptococcus neoformans and Cryptococcus gattii. Meningeal cryptococcosis is the most frequent clinical presentation of this disseminated mycosis. The oral mucosa involvement is extremely unusual.

Case report

We present a case of cryptococcosis with an unusual clinical form. The patient was assisted because she had an ulcerated lesion on the lingual mucosa. Encapsulated yeasts compatible with Cryptococcus were found in microscopic exams of wet preparations from lingual ulcer clinical samples obtained for cytodiagnosis and mycological studies. Cryptococcus neoformans (C. neoformans var. grubii VNI) was isolated in culture. This patient did not know her condition of HIV seropositive before the appearance of the tongue lesion.

Conclusions

The involvement of the oral mucosa is uncommon in this fungal infection, but is important to include it in the differential diagnosis in HIV positive patients.

中文翻译：

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新型隐球菌引起的舌头损伤是 HIV 阳性患者的首次发现

背景

隐球菌病是一种严重的普遍分布的真菌病，主要影响免疫功能低下的宿主。这种真菌病是由复杂的属的两个物种的酵母菌引起的隐：新型隐球菌和隐球菌gattii。脑膜隐球菌病是这种播散性真菌病最常见的临床表现。口腔黏膜受累极为罕见。

案例报告

我们介绍了一个具有不寻常临床形式的隐球菌病病例。患者得到帮助是因为她的舌粘膜有溃疡病灶。在从用于细胞诊断和真菌学研究获得的舌溃疡临床样本的湿制剂的显微镜检查中发现了与隐球菌相容的封装酵母。在培养物中分离出新型隐球菌（C. neoformans var. grubii VNI）。该患者在出现舌部病变之前并不知道她的 HIV 血清阳性状况。

结论

口腔黏膜受累在这种真菌感染中并不常见，但将其纳入 HIV 阳性患者的鉴别诊断中很重要。