In recent years, new molecular symmetry-based approaches for magnetic resonance have been invented. The implications of these discoveries will be significant for molecular imaging via magnetic resonance, in vitro as well as in vivo, for quantum computing and for other fields. Since the initial observation in 2004 in Southampton that effective spin symmetry can be instilled in a molecule during magnetic resonance experiments, spin states that are resilient to relaxation mechanisms have been increasingly used. Most of these states are related to the nuclear singlet in a pair of J-coupled spins. Tailored relaxation rate constants for magnetization became available in molecules of different sizes and structures, as experimental developments broadened the scope of symmetry-adapted spin states. The ensuing access to timescales longer by circa one order of magnitude than classically attained allows the study of processes such as slow diffusion or slow exchange that were previously beyond reach. Long-lived states formed by differences between populations of singlets and triplets have overcome the limitations imposed by longitudinal relaxation times (T₁) by factors up to 40. Long-lived coherences formed by superpositions of singlets and triplets have overcome the limit of classical transverse coherence (T₂) by a factor 9. We present here an overview of the development and applications of long-lived states (LLS) and long-lived coherences (LLC’s) and considerations on future perspectives.

近年来，已经发明了基于分子对称性的磁共振新方法。这些发现的含义将通过磁共振是用于分子成像的显著，在体外以及在体内，用于量子计算和用于其它领域。自从2004年在南安普敦首次观察到可以在磁共振实验期间将有效的自旋对称性注入分子以来，对松弛机制具有复原力的自旋态已得到越来越多的使用。这些状态大多数与一对J中的核单重态有关耦合自旋。随着实验的发展拓宽了对称适应自旋态的范围，可以在不同大小和结构的分子中使用量身定制的磁化弛豫速率常数。随之而来的时间尺度的访问时间比经典方法要长大约一个数量级，这使得人们可以研究以前无法达到的过程，例如缓慢扩散或缓慢交换。由单重态和三重态总体之间的差异形成的长寿命状态克服了纵向弛豫时间（T ₁）施加的限制高达40倍。由单重峰和三重态的叠加形成的长相干性克服了经典横向结构的局限性相干性（T ₂）的因素9。在此，我们概述了长寿状态（LLS）和长寿一致性（LLC's）的开发和应用以及对未来观点的考虑。