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Can coacervation unify disparate hypotheses in the origin of cellular life?
Current Opinion in Colloid & Interface Science ( IF 8.9 ) Pub Date : 2020-12-31 , DOI: 10.1016/j.cocis.2020.101415
Basusree Ghosh , Rudrarup Bose , T-Y. Dora Tang

Here, we review the recent progress in the characterisation and utilisation of coacervates as protocell models in the origin of life studies. We provide evidence that coacervation could have played a unique role during the origin of life, based on its ability to form from a range of different prebiotically relevant molecules; partition solutes; support and alter RNA catalysis and readily deform its shape. We discuss how these properties could have been important for the formation of the first membrane-bound cells, supporting RNA-peptide evolution and primitive metabolism, and in replicating and proliferating by growth and division processes.



中文翻译:

凝聚能统一细胞生命起源中不同的假设吗?

在这里,我们回顾了在生命研究起源中凝聚层作为原细胞模型的表征和利用方面的最新进展。我们提供的证据表明,凝聚能在生命起源中起着独特的作用,因为凝聚能由一系列不同的益生元相关分子形成。分配溶质 支持并改变RNA催化作用,并易于使其形状变形。我们讨论了这些特性如何对形成第一个膜结合细胞,支持RNA肽进化和原始代谢以及在通过生长和分裂过程进行复制和增殖中起重要作用。

更新日期:2021-02-19
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