Exosomal miRNAs (exo-miRNAs) derived from cancer cell play a vital role in cancer development and can be considered as a potential biomarker for cancer diagnostic. However, the shortage of sensitive preparatory and analytical technologies limits their clinical applications. Thus, sensitive and reliable sensing of exo-miRNAs is essential in medical diagnostics. Mounting number of biosensor strategies are thus actively being proposed to deal with these challenges, including nanoparticle, isothermal amplification, and microfluidic chips. Moreover, some delivery strategies have been found for individual exo-miRNAs detection, such as membrane fusion, nano-sized probe and membrane denatured. Therefore, we summarize and discuss the recent progress of emerging biosensor assays for sensing exo-miRNAs. In addition, challenges and outlook for exo-miRNAs detection are considered.

源自癌细胞的外泌体miRNA（exo-miRNA）在癌症发展中起着至关重要的作用，可以被认为是癌症诊断的潜在生物标记。但是，敏感的制备和分析技术的缺乏限制了其临床应用。因此，exo-miRNA的灵敏而可靠的传感在医学诊断中至关重要。因此，正在积极提出越来越多的生物传感器策略来应对这些挑战，包括纳米粒子，等温扩增和微流控芯片。此外，已经发现了一些用于个别exo-miRNA检测的递送策略，例如膜融合，纳米探针和变性膜。因此，我们总结并讨论了新兴的生物传感器检测exo-miRNA的最新进展。此外，