Sesbania grandiflora (L.) Pers. (Fabaceae) commonly called Agati or Vegetable Hummingbird, is autochthonal from Malaysia to North Australia; plant is cultivated in several parts of India. Root and bark paste is applied externally to relive pain and inflammation associated with arthritis. It has long been used as a traditional medicine for rheumatism. Keeping this in cognizance, the study was designed to explore the antirheumatic potential of S. grandiflora. The bark extracts were prepared and studied for their phytochemical study, in vitro antioxidant potential using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) radicals and antiarthritic activity against Complete Freund Adjuvant (CFA) induced arthritis. To probe into the causal mechanism of action, NFκB suppressing activity in paraventricular nucleus (PVN) of hypothalamus using potent extract was also studied. Polyphenol rich extract supplementation significantly normalizes the altered blood parameters and reverses the increase in paw thickness, a sign of arthritis in rats. Further, immunohistochemical analysis revealed significant reduction in the NFκB immunoreactive cells in 50% methanolic extract treated (14 days) arthritic rats (57%; p<0.001) as compared to control. These results consolidate the observation, that inhibition of NFκB may be a beneficial approach in the treatment of arthritis. This study corroborates the traditional use of S. grandiflora plant in rheumatism.

中文翻译：

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芝麻（Sesbania grandiflora）的富含多酚的提取物。树皮通过介导大鼠NF-κB的表达降低风湿病

大花田菁（L 。）个人 （Fabaceae）通常被称为Agati或蔬菜蜂鸟，从马来西亚到北澳大利亚都是自生的；该植物在印度的几个地方都有种植。根和树皮糊剂可从外部使用，以缓解与关节炎有关的疼痛和炎症。长期以来，它一直被用作风湿病的传统药物。保持这种认识，本研究旨在探索大花链球菌的抗风湿潜力。制备树皮提取物并进行体外植物化学研究使用2，2-二苯基-1-吡啶并肼基（DPPH）和一氧化氮（NO）自由基产生的抗氧化剂潜力以及对完全弗氏佐剂（CFA）诱发的关节炎的抗关节炎活性。为了探讨其作用机理，还研究了使用有效提取物抑制下丘脑室旁核（PVN）中NFκB活性的作用。富含多酚的提取物补充剂可以使正常的血液参数正常化，并可以逆转爪厚度的增加，这是大鼠关节炎的征兆。此外，免疫组织化学分析显示，与对照组相比，用50％甲醇提取物处理（14天）的关节炎大鼠（57％； p <0.001），NFκB免疫反应性细胞显着减少。这些结果巩固了这样的观察，即抑制NFκB可能是治疗关节炎的有益方法。风湿病的S. grandiflora植物。