Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation,Environmental Science & Technology

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Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2020-12-30 , DOI: 10.1021/acs.est.0c03758
Pengcheng Zhou _{1,

2,

3} , Ting Zheng ₁ , Yunping Li _{4,

5,

6} , Xin Zhang ₇ , Jinhong Feng ₁ , Yunbo Wei ₁ , Hao Wang ₂ , Yin Yao _{3,

8} , Fang Gong ₉ , Wenjing Tian ₁ , Lingyun Sun ₇ , Zheng Liu ₈ , Bin Zhao _{4,

5,

6} , Di Yu _{1,

2,

3}

Affiliation

Laboratory of Immunology for Environment and Health, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
The University of Queensland Diamantina Institute, Translational Research Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
University of Chinese Academy of Sciences, Beijing 100864, China
School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China
Department of Laboratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi 214122, China

Chlorinated flame-retardant dechloranes are emerging substitutes for restricted flame retardants. Recent studies have demonstrated that they are accumulated in wildlife and detectable in humans; however, their effects on human health are poorly understood. Here, for the first time, we revealed that widely used chlorinated flame-retardant dechlorane 602 (Dec 602) exacerbated airway inflammation in two mouse models induced by house dust mite (HDM) or IL-33, respectively. Deteriorated airway inflammation by Dec 602 was associated with a higher production of type 2 cytokines including IL-4, IL-5, and IL-13, and IgE, accompanied by enhanced mRNA expression of proinflammatory cytokines such as TNF-α and IL-6. Mechanistically, we found that Dec 602 directly potentiated mouse and human group 2 innate lymphoid cells and, as such, promoted airway inflammation even in the absence of conventional T cells in Rag^–/– mice. These findings provide novel immunological insights necessary for further studies of the health impact of emerging flame-retardant dechloranes including Dec 602.

中文翻译：

氯化阻燃二氯乙烷602增强2型先天淋巴样细胞并加剧气道炎症

氯化阻燃剂十氯烷是限制性阻燃剂的新兴替代品。最近的研究表明，它们是在野生生物中积累并在人类中可检测到的。但是，它们对人类健康的影响知之甚少。在这里，我们首次揭示了广泛使用的氯化阻燃性十氯烷602（Dec 602）在分别由室内尘螨（HDM）或IL-33诱导的两种小鼠模型中加剧了气道炎症。到602年12月，气道炎症恶化与2型细胞因子（包括IL-4，IL-5和IL-13和IgE）的更高产生有关，同时促炎性细胞因子（如TNF-α和IL-6）的mRNA表达增强。从机理上讲，我们发现Dec 602可直接增强小鼠和人类第2组先天淋巴样细胞的增殖，因此，抹布^{– / –}老鼠。这些发现提供了新的免疫学见解，对于进一步研究新兴的阻燃性十氯烷（包括Dec 602）的健康影响是必要的。

更新日期：2021-01-19

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