Objective. Cardiac autonomic neuropathy (CAN) is a common and serious complication of diabetes mellitus with various systemic involvements, such as atherosclerotic cardiovascular disease. We aimed to evaluate the association between CAN and coronary artery lesions in patients with type 2 diabetes. Research Design and Methods. We retrospectively reviewed the medical records of 104 patients with type 2 diabetes and coronary artery disease (CAD). We evaluated heart rate variability (HRV) parameters (SDANN, SDNN, and pNN50) to assess cardiac autonomic function. The severity of coronary lesions was assessed by the Gensini scores and the number of affected vessels. Correlation analyses between HRV parameters and the severity of coronary lesions and clinical parameters were performed. Results. Spearman’s correlation analysis showed a significant negative correlation between SDANN and Gensini scores (, ). Interestingly, this finding remained significant after adjusting for clinical covariates (, ). However, there was no association between HRV parameters and the severity of coronary lesions as assessed by the number of affected vessels. Clinical parameters were not significantly correlated with HRV parameters (all ). Conclusions. Cardiac autonomic neuropathy might be related to the degree of coronary atheromatous burden in patients with type 2 diabetes. Screening for cardiac autonomic neuropathy might potentially be beneficial in the risk stratification of patients with type 2 diabetes.

中文翻译：

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2型糖尿病患者心脏自主神经病变与冠状动脉病变的关系

客观的。心脏自主神经病变 (CAN) 是糖尿病常见且严重的并发症，伴有各种全身性受累，如动脉粥样硬化性心血管疾病。我们旨在评估 CAN 与 2 型糖尿病患者冠状动脉病变之间的关联。研究设计和方法。我们回顾性回顾了 104 例 2 型糖尿病合并冠状动脉疾病 (CAD) 患者的病历。我们评估了心率变异性 (HRV) 参数（SDANN、SDNN 和 pNN50）以评估心脏自主神经功能。通过 Gensini 评分和受影响血管的数量评估冠状动脉病变的严重程度。进行了HRV参数与冠状动脉病变严重程度和临床参数之间的相关性分析。结果。Spearman 的相关分析显示 SDANN 和 Gensini 得分之间存在显着的负相关（, ）。有趣的是，在调整了临床协变量后，这一发现仍然显着（, ）。然而，根据受影响血管的数量评估，HRV 参数与冠状动脉病变的严重程度之间没有关联。临床参数与 HRV 参数无显着相关性（所有）。 结论。心脏自主神经病变可能与 2 型糖尿病患者的冠状动脉粥样硬化负担程度有关。筛查心脏自主神经病变可能对 2 型糖尿病患者的风险分层有益。