Self-Assembled Multi- and Single-Chain Glyconanoparticles and Their Lectin Recognition,Biomacromolecules

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Self-Assembled Multi- and Single-Chain Glyconanoparticles and Their Lectin Recognition
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-29 , DOI: 10.1021/acs.biomac.0c01486
Yamin Abdouni ₁ , Gijs M Ter Huurne ₂ , Gokhan Yilmaz _{3,

4} , Alessandra Monaco _{1,

4} , Carlos Redondo-Gómez ₁ , E W Meijer ₂ , Anja R A Palmans ₂ , C Remzi Becer _{1,

4}

Affiliation

In this work, we describe the physicochemical characterization of amphiphilic glycopolymers synthesized via copper(0)-mediated reversible-deactivation radical polymerization (Cu-RDRP). Depending on the chemical composition of the polymer, these glycopolymers are able to form multi-chain or single-chain polymeric nanoparticles. The folding of these polymers is first of all driven by the amphiphilicity of the glycopolymers and furthermore by the supramolecular formation of helical supramolecular stacks of benzene-1,3,5-tricarboxamides (BTAs) stabilized by threefold hydrogen bonding. The obtained polymeric nanoparticles were subsequently evaluated for their lectin-binding affinity toward a series of mannose- and galactose-binding lectins via surface plasmon resonance. We found that addition of 2-ethylhexyl acrylate to the polymer composition results in compact particles, which translates to a reduction in binding affinity, whereas with the addition of BTAs, the relation between the nature of the particle and the binding ability system becomes more unpredictable.

中文翻译：

自组装的多链和单链糖醇纳米颗粒及其凝集素识别

在这项工作中，我们描述了通过铜（0）介导的可逆失活自由基聚合（Cu-RDRP）合成的两亲糖聚合物的理化特性。取决于聚合物的化学组成，这些糖聚合物能够形成多链或单链聚合物纳米颗粒。这些聚合物的折叠首先受到糖聚合物的两亲性的驱动，并且进一步受到通过三重氢键稳定的苯-1,3,5-三甲酰胺（BTA）的螺旋超分子堆叠的超分子形成的驱动。将得到的聚合物纳米颗粒随后评价朝向一系列甘露糖和半乳糖结合凝集素的凝集素的结合亲和力通过表面等离子体共振。我们发现，将丙烯酸2-乙基己酯添加到聚合物组合物中会导致紧密颗粒，这转化为结合亲和力的降低，而添加BTA时，颗粒性质与结合能力体系之间的关系变得更加不可预测。

更新日期：2021-02-08

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