VCells are constantly exposed to various types of stress, and disruption of the proper response lead to a variety of diseases. Among them, inflammation and apoptosis are important examples of critical responses and should be tightly regulated, as inappropriate control of these responses is detrimental to the organism. In several disease states, these responses are abnormally regulated, with adverse effects. Apoptosis signal-regulating kinase (ASK) family members are stress-responsive kinases that regulate inflammation and apoptosis after a variety of stimuli, such as oxidative stress and endoplasmic reticulum (ER) stress. In this review, we summarize recent reports on the ASK family in terms of their involvement in inflammatory diseases, focusing on upstream stimuli that regulate ASK family members.

中文翻译：

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ASK家族在应激诱导的炎症和细胞凋亡引起的疾病中的分子功能

VCell 不断暴露于各种类型的压力下，正常反应的中断会导致各种疾病。其中，炎症和细胞凋亡是关键反应的重要例子，应该受到严格监管，因为对这些反应的不当控制对生物体有害。在几种疾病状态下，这些反应受到异常调节，产生不利影响。凋亡信号调节激酶 (ASK) 家族成员是应激反应激酶，可在氧化应激和内质网 (ER) 应激等各种刺激后调节炎症和细胞凋亡。在这篇综述中，我们总结了 ASK 家族参与炎症性疾病的最新报告，重点关注调节 ASK 家族成员的上游刺激。