The Discovery of Multifunctional Chiral P Ligands for the Catalytic Construction of Quaternary Carbon/Silicon and Multiple Stereogenic Centers,Accounts of Chemical Research

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The Discovery of Multifunctional Chiral P Ligands for the Catalytic Construction of Quaternary Carbon/Silicon and Multiple Stereogenic Centers
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2020-12-30 , DOI: 10.1021/acs.accounts.0c00740
Fei Ye ₁ , Zheng Xu ₁ , Li-Wen Xu ₁

Affiliation

The development of highly effective chiral ligands is a key topic in enhancing the catalytic activity and selectivity in metal-catalyzed asymmetric synthesis. Traditionally, the difficulty of ligand synthesis, insufficient accuracy in controlling the stereoselectivity, and poor universality of the systems often become obstacles in this field. Using the concept of nonequivalent coordination to the metal, our group has designed and synthesized a series of new chiral catalysts to access various carbon/silicon and/or multiple stereogenic centers containing products with excellent chemo-, diastereo-, and enantioselectivity.

中文翻译：

多功能手性P配位体催化季碳/硅和多个立体中心的发现

高效手性配体的开发是提高金属催化不对称合成的催化活性和选择性的关键主题。传统上，配体合成的困难，控制立体选择性的准确性不足以及系统通用性差，经常成为该领域的障碍。使用与金属不等价配位的概念，我们小组设计和合成了一系列新的手性催化剂，可访问各种碳/硅和/或多个立体中心，这些中心含有具有出色的化学，非对映和对映选择性的产物。

更新日期：2021-01-19

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