Fungal disease is a major cause of morbidity and mortality in avian species; thus, antifungals are the treatment of choice. Despite widely used in clinical practice, terbinafine pharmacokinetic studies are scarce in literature and only cover some avian families, with marked differences between them. This study evaluates the pharmacokinetic behaviour of terbinafine after a single oral administration of 60 mg/kg in 7 healthy adult common shelducks (Tadorna tadorna) by measuring plasma concentrations through high-performance liquid chromatography (HPLC) at times 0, 30 min, 1, 2, 4, 6, 8, 10, 12, 24, 36 and 48 hr postadministration. Noncompartmental analyses of the data showed a C_max (geometric mean) of 5.43 µg/ml, t_max (median) 1.0 hr and AUC_0-∞ 29.70 mg h/L. Elimination half-life was 6.33 hr and MRT 6.61 hr. Plasma concentrations remained above previously described MIC for terbinafine in some fungal species for at least 6 to 8 hr. A single oral administration of 60 mg/kg terbinafine did not produce adverse effects and could be a good treatment choice for fungal diseases in anatids.

中文翻译：

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单剂量口服特比萘芬在普通鸭（Tadorna tadorna）中的药代动力学

真菌病是鸟类发病和死亡的主要原因；因此，抗真菌药物是首选治疗方法。特比萘芬的药代动力学研究虽然在临床上得到广泛应用，但文献中很少见，仅涉及部分禽科，两者之间存在显着差异。本研究评估特比萘芬在7个健康成年共同麻鸭的60mg / kg的单次口服给药后的药代动力学行为（赤赤通过测量通过高效液相色谱法（HPLC）在时间0，30分钟，1血浆浓度），给药后 2、4、6、8、10、12、24、36 和 48 小时。数据的非房室分析显示 C _max（几何平均值）为 5.43 µg/ml，t _max（中值）为 1.0 小时，AUC 为_0-∞29.70 毫克小时/升。消除半衰期为 6.33 小时，MRT 为 6.61 小时。血浆浓度在某些真菌物种中保持高于先前描述的特比萘芬 MIC 至少 6 至 8 小时。单次口服 60 mg/kg 特比萘芬不会产生不良反应，可能是治疗抗真菌真菌病的良好选择。