Dexmedetomidine protects cardiac microvascular endothelial cells from the damage of ogd/r through regulation of the pparδ-mediated autophagy,Microcirculation

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Dexmedetomidine protects cardiac microvascular endothelial cells from the damage of ogd/r through regulation of the pparδ-mediated autophagy
Microcirculation ( IF 1.9 ) Pub Date : 2020-12-30 , DOI: 10.1111/micc.12675
Qingbo Shao ₁ , Jing Xia ₂ , Pinwen Wu ₁ , Jiazhou Ying ₁

Affiliation

Dexmedetomidine (Dex) exerts an effective therapeutic role in numerous diseases associated with ischemia/reperfusion (I/R) injury via its anti‑apoptosis properties. Therefore, this study explores the cardioprotective effects of Dex in cardiac microvascular endothelial cells (CMECs) in response to oxygen-glucose deprivation and re-oxygenation (OGD/R) injury and its potential mechanism.

中文翻译：

右美托咪定通过调节 pparδ 介导的自噬保护心脏微血管内皮细胞免受 ogd/r 损伤

右美托咪定 (Dex) 通过其抗细胞凋亡特性在许多与缺血/再灌注 (I/R) 损伤相关的疾病中发挥有效的治疗作用。因此，本研究探讨了 Dex 在心脏微血管内皮细胞 (CMECs) 中对氧-葡萄糖剥夺和再氧合 (OGD/R) 损伤的心脏保护作用及其潜在机制。

更新日期：2020-12-30

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