Chromatography‐Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur,ChemistryOpen

当前位置： X-MOL 学术 › Chemistryopen › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Chromatography‐Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur
ChemistryOpen ( IF 2.5 ) Pub Date : 2020-12-30 , DOI: 10.1002/open.202000250
András Gy Németh ₁ , Renáta Szabó ₁ , Attila Domján ₂ , György M Keserű ₁ , Péter Ábrányi-Balogh ₁

Affiliation

The development of a new three‐component chromatography‐free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.

中文翻译：

单质硫水溶液无需色谱法多组分合成硫脲

异氰化物、胺和元素硫的新型三组分无色谱反应的开发使我们能够在水中直接合成硫脲。考虑到大量的有机和无机碱，我们首先优化了从元素硫制备多硫化物水溶液的方法。使用多硫化物溶液，我们能够省略原本必须进行的色谱法，并通过简单的过滤直接从反应混合物中分离结晶产物，将硫保留在溶液相中。以这种方式合成的各种硫脲证实了我们的方案的合理底物和官能团耐受性。

更新日期：2021-01-04

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11