Obesity is a complex disease with many causes, including a possible role for environmental chemicals. Perfluorohexane sulfonate (PFHxS) is one of many per- and polyfluoroalkyl substances (PFASs) frequently detected in humans and it is suspected to be an obesogenic compound. We examined the potential long-term effects of PFHxS on metabolic parameters in rats after developmental exposure to 0.05, 5 or 25 mg/kg bw/day, with or without co-exposure to a background mixture of twelve endocrine disrupting chemicals (EDmix). Both male and female offspring showed signs of lower birth weight following intrauterine exposure. Female offspring exposed to both PFHxS and EDmix had increased body weight in adulthood. The retroperitoneal fat pad was larger in the PFHxS-exposed female offspring when compared to those exposed to EDmix alone. An attempt to detect putative molecular markers in the fat tissue by performing whole transcriptome profiling revealed no significant changes between groups and there were no significant effects on plasma leptin levels in exposed females. Our results show that early life exposure to endocrine disrupting chemicals can influence body weight later in life, but the effect is not necessarily reflected in changed gene expression in the fat tissue.

中文翻译：

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围产期暴露于全氟己烷磺酸 (PFHxS) 和内分泌干扰物混合物的成年雌性大鼠表现出增加的体重/脂肪重量，而脂肪细胞中没有转录足迹

肥胖是一种复杂的疾病，有多种原因，包括环境化学物质的可能作用。全氟己烷磺酸 (PFHxS) 是在人体中经常检测到的多种全氟和多氟烷基物质 (PFAS) 之一，并且被怀疑是一种致胖化合物。我们研究了全氟己烷磺酸对大鼠在发育过程中暴露于 0.05、5 或 25 毫克/千克体重/天后代谢参数的潜在长期影响，无论是否同时暴露于十二种内分泌干扰化学品（EDmix）的背景混合物。在宫内暴露后，雄性和雌性后代均表现出较低的出生体重迹象。暴露于全氟己烷磺酸和 EDmix 的雌性后代在成年期体重增加。与单独接触 EDmix 的雌性后代相比，接触 PFHxS 的雌性后代的腹膜后脂肪垫更大。通过进行全转录组分析来检测脂肪组织中推定的分子标记物的尝试表明，组间没有显着变化，并且对暴露女性的血浆瘦素水平没有显着影响。我们的结果表明，生命早期暴露于内分泌干扰化学物质会影响生命后期的体重，但这种影响不一定反映在脂肪组织中基因表达的改变上。