A pigment-protein highly dominant in Spirulina is known as C-Phycocyanin. Earlier, in vitro studies has shown that C-phycocyanin is having many biological activities like antioxidant and anti-inflammatory activities, antiplatelet, hepatoprotective, and cholesterol-lowering properties. Interestingly, there are scanty in vivo experimental findings on the immunomodulatory and antioxidant effects of C-phycocyanin. This work is aimed at in vivo evaluation of the effects of C-phycocyanin on immunomodulation and antioxidant potential in Balb/c mice. Our results of in vivo toxicity, immunomodulatory and antioxidant effects of C-Phycocyanin suggests that C-phycocyanin is very safe for consumption and having substantial antioxidant potential and also possess immunomodulatory activities in Balb/c mice in a dosage dependent manner. C-phycocyanin doesn’t cause acute and subacute toxicity in the animal model (male, Balb/c mice) studied. We have reported that C-phycocyanin exhibited in vivo immunomodulation performance in this animal model.

在螺旋藻中高度占优势的色素蛋白被称为C-藻蓝蛋白。早期的体外研究表明，C-藻蓝蛋白具有许多生物活性，例如抗氧化剂和抗炎活性，抗血小板，保肝和降低胆固醇的特性。有趣的是，关于C-藻蓝蛋白的免疫调节和抗氧化作用的体内实验研究很少。这项工作旨在体内评估C-藻蓝蛋白对Balb / c小鼠免疫调节和抗氧化能力的影响。我们的体内结果C-藻蓝蛋白的毒性，免疫调节和抗氧化作用表明，C-藻蓝蛋白对于食用非常安全，具有很大的抗氧化潜能，并且在Balb / c小鼠中具有剂量依赖性的免疫调节活性。在研究的动物模型（雄性，Balb / c小鼠）中，C-藻蓝蛋白不会引起急性和亚急性毒性。我们已经报道了C-藻蓝蛋白在这种动物模型中表现出体内免疫调节性能。