BACKGROUND Epilepsy is a common and debilitating neurological disorder. Disease prognosis depends on the quality of patient life with regard to its cognitive, behavioral, and social aspects and is not restricted to the frequency or severity of epileptic seizures. AIMS To recognize the seizure types in a Jordanian Arab population with pediatric epilepsy and to explore the clinical and medication-related factors that may affect the responsiveness and satisfaction with the treatments. METHODS A total of 300 pediatric patients (age range: 1-month to 14-years) with epilepsy were recruited. The patients were categorized into two groups, focal onset and generalized onset epilepsy. RESULTS The majority of patients (195) suffered from idiopathic epilepsy, and the majority were using only one medication, with valproic acid being the most frequently used. There was significant association between patient gender and the incidence of psychotic thoughts (P-value = 0.019), and between seizure type and the history of febrile seizures (P-value = 0.02). However, the numbers of psychotic patients (n = 13) and patients with history of febrile seizures (n = 25) were relatively small. Moreover, the number of medications used to control the seizures was significantly associated with the age of onset, type of epilepsy syndrome, and patients' response to the first trialed medication, with P-values of 0.006, 0.001, and 0.0001, respectively. CONCLUSIONS This is the first study comprehensively analyzed the clinical and demographic characteristics that affect therapeutic response of Jordanian-Arab epileptic and pediatric patients. Our results contribute to the understanding and improvement of current diagnostic and therapeutic procedures in epilepsy.

中文翻译：

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约旦的一项研究，评估可能影响儿科患者抗癫痫治疗反应的因素


背景技术癫痫是一种常见且使人衰弱的神经系统疾病。疾病预后取决于患者在认知、行为和社会方面的生活质量，并且不限于癫痫发作的频率或严重程度。目的 识别约旦阿拉伯儿童癫痫患者的癫痫发作类型，并探讨可能影响治疗反应和满意度的临床和药物相关因素。方法 总共招募了 300 名癫痫儿科患者（年龄范围：1 个月至 14 岁）。患者被分为两组：局灶性癫痫和全身性癫痫。结果 大多数患者（195 名）患有特发性癫痫，并且大多数只使用一种药物，其中丙戊酸是最常用的。患者性别与精神病性想法的发生率之间存在显着相关性（P 值= 0.019），癫痫发作类型与热性惊厥病史之间也存在显着相关性（P 值= 0.02）。然而，精神病患者（n = 13）和有热性惊厥病史的患者（n = 25）数量相对较少。此外，用于控制癫痫发作的药物数量与发病年龄、癫痫综合征类型以及患者对首次试验药物的反应显着相关，P 值分别为 0.006、0.001 和 0.0001。结论 这是第一项全面分析影响约旦-阿拉伯癫痫和儿科患者治疗反应的临床和人口特征的研究。我们的结果有助于理解和改进当前癫痫的诊断和治疗程序。