Objectives

Inflammation plays an important role in the development of atherosclerotic vascular disease, which is the leading cause of morbidity and mortality in the adult population. Several clinical trials have shown that suppression of the inflammatory response can delay or decrease the atherosclerotic process. The aim of this study was to investigate carotid intima-media thickness (CIMT) between patients with chronic disease history plus gout using colchicine and patients with cardiovascular risk factors.

Materials and Methods

In total, 102 patients (85 female, 17 male) were included. There were two groups in the study: Group 1 – patients with chronic diseases including cardiovascular risk factors plus gout using colchicine (0,5 mg twice a day); and Group 2 – patients with chronic diseases including cardiovascular risk factors only. All patients underwent ultrasonography for the measurement of CIMT. Additionally, the serum concentrations of C-reactive protein (CRP) and the levels of lipids such as cholesterol, triglyceride, LDL, HDL were measured.

Results

The mean age of patients was 62.35±6.68 years and 64.27±5.32 years in Group 1 and Group 2, respectively. There was also no statistically significant difference in the levels of lipids between groups (p>0.05). The value of CIMT and CRP in Group 1 and Group 2 were 0.98±0.20 and 0.26±0.14, 1.18±0.15 and 0.58±0.42, respectively. There was a statistically significant difference between groups (p<0.05). The colchicine group was found to have a statistically significant lowering of CIMT and CRP compared to the non-colchicine group.

Conclusions

It appears that colchicine in addition to statins and other standard treatments is an effective treatment for the interception of cardiovascular and cerebrovascular events in patients with cardiovascular risk factors.

中文翻译：

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秋水仙碱对颈动脉内膜中层厚度的影响：前瞻性比较研究

目标

炎症在动脉粥样硬化性血管疾病的发展中起着重要作用，这是成年人口发病和死亡的主要原因。多项临床试验表明，抑制炎症反应可以延迟或减少动脉粥样硬化过程。这项研究的目的是研究慢性疾病史加痛风使用秋水仙碱的患者和有心血管危险因素的患者之间的颈动脉内中膜厚度（CIMT）。

材料和方法

总共包括102例患者（85例女性，17例男性）。该研究分为两组：第一组-患有慢性疾病的患者，包括心血管危险因素和使用秋水仙碱的痛风（每天两次0.5 mg）；第2组-仅包括心血管危险因素的慢性疾病患者。所有患者均接受了超声检查以测量CIMT。此外，还测量了血清C反应蛋白（CRP）浓度和脂质水平，例如胆固醇，甘油三酸酯，LDL，HDL。

结果

第一组和第二组患者的平均年龄分别为62.35±6.68岁和64.27±5.32岁。两组之间的脂质水平也没有统计学上的显着差异（p > 0.05）。第1组和第2组的CIMT和CRP值分别为0.98±0.20和0.26±0.14、1.18±0.15和0.58±0.42。两组之间存在统计学差异（p <0.05）。与非秋水仙碱组相比，秋水仙碱组的CIMT和CRP降低具有统计学意义。

结论

似乎秋水仙碱除他汀类药物和其他标准疗法外，对于拦截具有心血管危险因素的心血管和脑血管事件也是一种有效的治疗方法。