One in 113-178 females worldwide carry a premutation allele on the FMR1 gene. The FMR1 premutation is linked to neurocognitive and neuromotor impairments, although the phenotype is not fully understood, particularly with respect to age effects. This study sought to define oculomotor response inhibition skills in women with the FMR1 premutation and their association with age and fall risk. We employed an antisaccade eye-tracking paradigm to index oculomotor inhibition skills in 35 women with the FMR1 premutation and 28 control women. The FMR1 premutation group exhibited longer antisaccade latency and reduced accuracy relative to controls, indicating deficient response inhibition skills. Longer response latency was associated with older age in the FMR1 premutation and was also predictive of fall risk. Findings highlight the utility of the antisaccade paradigm for detecting early signs of age-related executive decline in the FMR1 premutation, which is related to fall risk. Findings support the need for clinical prevention efforts to decrease and delay the trajectory of age-related executive decline in women with the FMR1 premutation during midlife.

全世界每 113-178 名女性中就有一名携带FMR1基因的前突变等位基因。FMR1前突变与神经认知和神经运动障碍有关，尽管表型尚未完全了解，特别是在年龄影响方面。本研究旨在确定具有FMR1前突变的女性的动眼神经反应抑制技能及其与年龄和跌倒风险的关系。我们采用antisaccade 眼动追踪范例来索引35 名FMR1前突变女性和28 名对照女性的动眼神经抑制技能。FMR1 _与对照组相比，前突变组表现出更长的抗眼跳潜伏期和降低的准确性，表明反应抑制技能不足。较长的反应潜伏期与FMR1前突变的年龄较大有关，也可预测跌倒风险。研究结果强调了antisaccade范式在检测与跌倒风险有关的FMR1前突变中与年龄相关的执行能力下降的早期迹象的效用。研究结果支持临床预防工作的必要性，以减少和延缓中年FMR1前突变女性与年龄相关的执行能力下降的轨迹。