Abstract

This work is devoted to a comparative study of pharmacokinetic properties of complex compounds labeled with gallium-68 aminoglucose (⁶⁸Ga-NODA-AG) or thioglucose (⁶⁸Ga-NODA-TG) in BALB/c mice after intravenous administration. Statistical significance of activity accumulation in most organs and tissues was observed only at 5 min post-injection. At the following terms, these values didn’t have any statistical significance in most organs and tissues. Activity was eliminated from organs and tissues with high rate. The biological and effective half-lives of ⁶⁸Ga-NODA-AG and ⁶⁸Ga-NODA-TG from organs and tissues were less than 1 hour.

中文翻译：

---

实验室动物中葡萄糖衍生物中掺入的68G放射性核素的行为特征

摘要

这项工作致力于比较静脉注射给药后在BALB / c小鼠中用镓68氨基葡萄糖（⁶⁸ Ga-NODA-AG）或硫代葡萄糖（⁶⁸ Ga-NODA-TG）标记的复杂化合物的药代动力学特性的比较研究。仅在注射后5分钟观察到大多数器官和组织中活性积累的统计显着性。在以下术语中，这些值在大多数器官和组织中没有任何统计学意义。从器官和组织中消除活性的比率很高。⁶⁸ Ga-NODA-AG和⁶⁸ Ga-NODA-TG来自器官和组织的生物学和有效半衰期均小于1小时。