Background:The three-month, multidomain Memory Boot Camp program incorporates z-score neurofeedback (NFB), heart rate variability (HRV) biofeedback, and one-on-one coaching to teach memory skills and encourage behavior change in diet, sleep, physical fitness, and stress reduction. Objective:This prospective trial evaluates the Memory Boot Camp program for adults ages 55 to 85 with symptoms of Mild Cognitive Impairment (MCI) and subjective memory complaints. Methods:Participants were evaluated via the Montreal Cognitive Assessment (MoCA), NeuroTrax Global Cognitive Index, measures of anxiety, depression, sleep, quality of life, quantitative electroencephalography (QEEG), and HRV parameters at four timepoints: baseline, pre-program, post-program, and follow-up. The trial included a three-month waiting period between baseline and pre-program, such that each participant acted as their own control, and follow-up took place six months after completion of the program. Results:Participants’ MoCA scores and self-reported measures of anxiety, depression, sleep quality, and quality of life improved after treatment, and these changes were maintained at follow-up. Physiological changes in HRV parameters after treatment were not significant, however, breathing rate and QEEG parameters were improved at post-program and maintained at follow-up. Finally, participants’ improvement in MoCA score over the treatment period was correlated with their improvement in two brain oscillation parameters targeted by the z-score NFB protocol: relative power of delta and relative power of theta. Conclusions:Trial results suggest that the Memory Boot Camp program is a promising treatment strategy for older adults with symptoms of MCI and subjective memory complaints.

中文翻译：

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Z 分数神经反馈、心率变异性生物反馈以及针对有记忆问题的老年人的大脑辅导


背景：为期三个月的多领域记忆训练营计划结合了 z 分数神经反馈 (NFB)、心率变异性 (HRV) 生物反馈和一对一辅导，教授记忆技能并鼓励饮食、睡眠、身体方面的行为改变。健身、减压。目的：这项前瞻性试验评估了针对 55 至 85 岁有轻度认知障碍 (MCI) 症状和主观记忆抱怨的成年人的记忆训练营计划。方法：通过蒙特利尔认知评估 (MoCA)、NeuroTrax 全球认知指数、焦虑、抑郁、睡眠、生活质量测量、定量脑电图 (QEEG) 和 HRV 参数在四个时间点对参与者进行评估：基线、预计划、计划后和后续行动。该试验包括基线和预计划之间的三个月等待期，以便每个参与者充当自己的对照，并在计划完成六个月后进行随访。结果：治疗后，参与者的 MoCA 评分以及自我报告的焦虑、抑郁、睡眠质量和生活质量指标均有所改善，并且这些变化在随访中得以维持。治疗后 HRV 参数的生理变化并不显着，但呼吸频率和 QEEG 参数在治疗后有所改善，并在随访中保持不变。最后，参与者在治疗期间 MoCA 评分的改善与 z 评分 NFB 方案所针对的两个脑振荡参数的改善相关：δ 的相对功率和 θ 的相对功率。结论：试验结果表明，记忆训练营计划对于患有 MCI 症状和主观记忆抱怨的老年人来说是一种有前景的治疗策略。